Review ArticlesIntegrative Therapies for Cancer-Related FatigueArring, Noël M. DNP, PhD, RN, OCN∗; Barton, Debra L. PhD, FAAN, RN∗; Brooks, Trevor MSW∗; Zick, Suzanna M. ND, MPH†,‡ Author Information From the ∗Michigan School of Nursing, University of Michigan †Department of Family Medicine, University of Michigan Health System ‡Department of Nutritional Sciences, School of Public Health, University of Michigan, University of Michigan, Ann Arbor, MI. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Reprints: Suzanna M. Zick, ND, MPH, 24 Frank Lloyd Wright, Lobby M, Rm 2138, Department of Family Medicine, University of Michigan, Ann Arbor, MI 48105. E-mail: [email protected]. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.journalppo.com). The Cancer Journal 25(5):p 349-356, 9/10 2019. | DOI: 10.1097/PPO.0000000000000396 Buy SDC Metrics Abstract Cancer-related fatigue (CRF) is a common symptom for which cancer patients often use integrative and integrative therapies; however, evidence supporting these therapies is limited. The aim of this review is to provide evidence-based recommendations for integrative interventions during and after cancer treatment for CRF. These recommendations are based on a systematic literature review from 1990 through 2019. Cognitive behavior therapy plus hypnosis and American ginseng can be considered during active treatment, and acupressure, mindfulness-based cognitive therapy, and qigong/tai chi easy can be considered during posttreatment. Coenzyme Q10 and l-carnitine are not recommended during active-treatment. All other integrative therapies for CRF had insufficient evidence to make a recommendation. While there is increasing evidence for integrative therapies for CRF, because of lack of rigorous trials and replication, no therapies could be definitively recommended. Further rigorously designed integrative therapy research is needed and should consider implementation and dissemination. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.