Review ArticlesAntibody Drug Conjugates in Lung CancerMerle, Geoffrey MD∗; Friedlaender, Alex MD†; Desai, Aakash MD‡; Addeo, Alfredo MD∗ Author Information From the ∗Oncology Department, University Hospital Geneva, Geneva, Switzerland †Oncology Unit, Clinique Beaulieu ‡Division of Medical Oncology, Mayo Clinic, Rochester, MN. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Reprints: Alfredo Addeo, MD, Hopitaux Universitaires Geneve, Boulevard de la Cluse 30, 1205 Geneva, Switzerland. E-mail: [email protected]. The Cancer Journal: 11/12 2022 - Volume 28 - Issue 6 - p 429-435 doi: 10.1097/PPO.0000000000000630 Buy Metrics Abstract An antibody-drug conjugate (ADC) comprises a monoclonal antibody that is specific to a tumor cell protein, bound to a cytotoxic agent, known as the payload. The use of ADCs is already common practice in several cancers, thanks to their efficacy and potentially more manageable toxicity profile, resulting from the release of the cytostatic payload directly in the tumors. Currently, early-phase trials of ADCs in non–small cell lung cancer are rapidly gaining ground, with promising results targeting HER2 (human epidermal growth factor 2), HER3, TROP2 (trophoblast cell surface antigen 2), MET, CEACAM5 (carcinoembryonic antigen–related cell adhesion molecule 5), and PTK7 (tyrosine protein kinase–like 7). Unfortunately, in small cell lung cancer, trials targeting the ubiquitous DLL3 (delta-like ligand 3) protein have failed to show clinically relevant results, despite significant toxicity. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.