Review ArticlesRole of Microenvironment in Non-Hodgkin Lymphoma Understanding the Composition and BiologyKhurana, Arushi MBBS; Ansell, Stephen M. MD, PhDAuthor Information From the Division of Hematology, Mayo Clinic, Rochester, MN. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Reprints: Stephen M. Ansell, MD, PhD, Division of Hematology, Mayo Clinic, 200 First Street, Rochester, MN 55905. E-mail: Ansell.Stephen@mayo.edu. The Cancer Journal: 5/6 2020 - Volume 26 - Issue 3 - p 206-216 doi: 10.1097/PPO.0000000000000446 Buy Metrics Abstract Lymphoma microenvironment is a dynamic and well-orchestrated network of various immune and stromal cells that is indispensable for tumor cell survival, growth, migration, immune escape, and drug resistance. Recent progress has enhanced our knowledge of the pivotal role of microenvironment in lymphomagenesis. Understanding the characteristics, functions, and contributions of various components of the tumor niche, along with its bidirectional interactions with tumor cells, is paramount. It offers the potential to identify new therapeutic targets with the ability to restore antitumor immune surveillance and eliminate the protumoral factors contributed by the tumor niche. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.