Review ArticlesLymphoma Classificationde Leval, Laurence MD, PhD∗; Jaffe, Elaine S. MD† Author Information From the ∗Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland †Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Reprints: Laurence de Leval, MD, PhD, Institute of Pathology, University Hospital Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland. E-mail: [email protected]. The Cancer Journal 26(3):p 176-185, 5/6 2020. | DOI: 10.1097/PPO.0000000000000451 Buy Metrics Abstract Twenty-five years after the Revised European American Classification of Lymphoid Neoplasms classification was published, its principle of an integrative approach to disease definition based on several parameters still prevails and has been adopted and expanded in the following World Health Organization classifications of tumors of the hematopoietic organs. The latest World Health Organization classification revised in 2017 comprises more than 80 entities of mature lymphoid neoplasms (B-cell, T-cell, and Hodgkin lymphomas), which are defined according to their morphology, immunophenotype, genetic lesions and molecular profiles, clinical features, and cellular derivation. The classification also recognizes both incipient and indolent lymphoid neoplasms with a low potential of progression. In this review, we highlight some of the new data and recent modifications introduced in the 2017 classification. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.