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Geriatric Assessment and Tools for Predicting Treatment Toxicity in Older Adults With Cancer

Li, Daneng, MD; Soto-Perez-de-Celis, Enrique, MD; Hurria, Arti, MD

doi: 10.1097/PPO.0000000000000269
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Cancer is a disease of older adults, and the majority of new cancer cases and deaths occur in people 65 years or older. However, fewer data are available regarding the risks and benefits of cancer treatment in older adults, and commonly used assessments in oncology fail to adequately evaluate factors that affect treatment efficacy and outcomes in the older patients. The geriatric assessment is a multidisciplinary evaluation that provides detailed information about a patient’s functional status, comorbidities, psychological state, social support, nutritional status, and cognitive function. Among older patients with cancer, geriatric assessment has been shown to identify patients at risk of poorer overall survival, and geriatric assessment-based tools are significantly more effective in predicting chemotherapy toxicity than other currently utilized measures. In this review, we summarize the components of the geriatric assessment and provide information about existing tools used to predict treatment toxicity in older patients with cancer.

From the Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA.

D.L. and E.S.-P.-C. made equal contributions to this study.

Conflicts of Interest and Source of Funding: E.S.-P.-C. is supported by a Long Term International Fellowship from the Conquer Cancer Foundation of the American Society of Clinical Oncology. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Reprints: Arti Hurria, MD, Department of Medical Oncology and Therapeutics Research, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010. E-mail: ahurria@coh.org.

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