Review ArticlesNew Developments in Interventional Oncology Liver Metastases From Colorectal CancerKallini, Joseph R. MD; Gabr, Ahmed MD; Abouchaleh, Nadine MD; Ali, Rehan MD; Riaz, Ahsun MD; Lewandowski, Robert J. MD; Salem, Riad MD, MBAAuthor Information From the *Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center; †Department of Surgery, Division of Transplantation, Comprehensive Transplant Center; and ‡Department of Medicine, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL. There was no funding provided for this study. Conflicts of Interest and Source of Funding: R.S. is an advisor to BTG international. For the remaining authors, none were declared. Reprints: Riad Salem, MD, MBA, Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, 676 N. St Clair, Suite 800, Chicago, IL 60611. E-mail: [email protected]. The Cancer Journal: November/December 2016 - Volume 22 - Issue 6 - p 373-380 doi: 10.1097/PPO.0000000000000226 Buy Metrics Abstract Colorectal cancer is the third leading cause of cancer death in the United States. Although hepatic excision is the first-line treatment for colorectal liver metastasis (CRLM), few patients are candidates. Locoregional therapy (LRT) encompasses minimally invasive techniques practiced by interventional radiology. These include ablative treatments (radiofrequency ablation, microwave ablation, and cryosurgical ablation) and transcatheter intra-arterial therapy (hepatic arterial infusion chemotherapy, transarterial “bland” embolization, transarterial chemoembolization, and radioembolization with yttrium 90). The National Comprehensive Cancer Network recommends LRT for unresectable CRLM refractory to chemotherapy. The following is a review of LRT in CRLM, including salient features, advantages, limitations, current roles, and future considerations. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.