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Chemotherapy for Advanced-Stage Non–Small Cell Lung Cancer

Du, Lingling MD; Morgensztern, Daniel MD

doi: 10.1097/PPO.0000000000000141

Use of platinum-based chemotherapy doublets is the standard of care for patients with advanced-stage non–small cell lung cancer, being associated with improved survival compared with best supportive care in fit patients with good performance status. Randomized studies showed that the addition of monoclonal antibodies against vascular endothelial growth factor receptor or epidermal growth factor receptor may increase the survival compared to chemotherapy alone. Patients with either advanced age or poor performance status can also benefit from chemotherapy. Docetaxel with or without ramucirumab, pemetrexed, and erlotinib are approved for previously treated patients. New treatment approaches are needed to improve the outcomes in this patient population.

From the Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO.

Reprints: Daniel Morgensztern, MD, Division of Medical Oncology, Washington University School of Medicine, 660 S Euclid, Box 8056, St Louis, MO 63110. E-mail:

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