The tumor microenvironment (TME) is a complex, heterogeneous, and dominant component of solid tumors. Cancer imaging strategies of a subset of characteristics of the TME are under active development, and currently used modalities and novel approaches are summarized in this article. Understanding the dynamic and evolving functions of the TME is critical to accurately inform imaging and clinical care of cancer. Novel insights into distinct roles of the TME in cancer progression urge careful interpretation of imaging data and impel the development of novel modalities.
From the Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX.
VSL is supported by the NIH/NCI CCSG New Faculty Award P30CA016672 and UT MDACC Khalifa Bin Zayed Al Nahya Foundation.
The author has disclosed that she has no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
Reprints: Valerie LeBleu, PhD, Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, P3SCR5.3420 (Unit 1906), Houston, TX. E-mail: firstname.lastname@example.org.