ReviewsChallenges of Pancreatic CancerDimastromatteo, Julien PhD*; Houghton, Jacob L. PhD†; Lewis, Jason S. PhD†; Kelly, Kimberly A. PhD*Author Information From the *Biomedical Engineering Department, University of Virginia, Robert M. Berne Cardiovascular Research Center, Charlottesville, VA; †Department of Radiology and the Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY. J.D. and J.L.H. contributed equally to this work. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Reprints: Kimberly A. Kelly, PhD, Biomedical Engineering Department, University of Virginia, Robert M. Berne Cardiovascular Research Center, 415 Lane Rd, Bldg MR5, Rm 1214, Charlottesville, VA 22908. E-mail: [email protected]. The Cancer Journal: May/June 2015 - Volume 21 - Issue 3 - p 188-193 doi: 10.1097/PPO.0000000000000109 Buy Metrics Abstract The development of novel molecular cancer imaging agents has considerably advanced in recent years. Numerous cancer imaging agents have demonstrated remarkable potential for aiding the diagnosis, staging, and treatment planning at the preclinical stage, which in turn has led to a number of agents being approved for human trials. Pancreatic ductal adenocarcinoma is currently the most deadly common carcinoma with an overall 5-year survival rate of about 6%. As detection technologies progress, the need for molecular imaging tools that will allow the diagnosis at an early stage will be crucial to improving patient outcomes. In this review, we will highlight agents that illuminate various cell populations that comprise the tumor: epithelial, endothelial, and stromal tumor cells. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.