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Histopathology of Hodgkin’s Lymphoma

Eberle, Franziska C. MD; Mani, Haresh MD; Jaffe, Elaine S. MD

doi: 10.1097/PPO.0b013e31819e31cf
Special Issue on Hodgkin's Lymphoma: Original Article

In the last few years, there has been a greater understanding of the spectrum and biology of Hodgkin’s lymphoma. In standard texts, Hodgkin’s lymphoma is classified as 2 distinct entities, namely nodular lymphocyte predominant Hodgkin’s lymphoma and classical Hodgkin’s lymphoma. However, recent evidence suggests that classical Hodgkin’s lymphoma is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes may be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis Hodgkin’s lymphoma, particularly those cases presenting with mediastinal disease, also seems related to primary mediastinal B-cell lymphoma. As Hodgkin’s lymphoma is a B-cell neoplasm, there is also a better appreciation today of cases that may be borderline with conventional B-cell lymphomas. We present an update on the histopathological features of Hodgkin’s lymphoma and the immunohistochemical tools available for diagnosis in the clinical setting.

From the Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Reprints: Elaine S. Jaffe, MD, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. E-mail:

© 2009 Lippincott Williams & Wilkins, Inc.