Clinical Manifestations and Natural History of Hodgkin’s LymphomaConnors, Joseph M. MDThe Cancer Journal: March-April 2009 - Volume 15 - Issue 2 - p 124-128 doi: 10.1097/PPO.0b013e3181a282d8 Special Issue on Hodgkin's Lymphoma: Original Article Abstract Author Information Hodgkin’s lymphoma usually presents with typical lymphadenopathy that has been detected either incidentally by the patient or by imaging procedures performed for assessment of other conditions. Occasionally, it may be detected when investigation of nonspecific symptoms, such as fever, fatigue, or unexplained pain prompt assessment that, in turn reveals a mass lesion. The diagnosis must be confirmed with an appropriate biopsy. Nowadays, clinicians usually have little difficulty making the diagnosis of Hodgkin’s lymphoma. Knowledge of the usual pattern of spread of this lymphoma, with its orderly progression through lymph node groups and its typical forms of extranodal involvement, facilitates timely diagnosis, staging, and treatment planning. Rare manifestations due to involvement of unusual sites or presentation with paraneoplastic organ dysfunction can prove challenging but a search for mass lesions and an appreciation of these uncommonly encountered findings as potential clues to the presence of Hodgkin’s lymphoma usually prompts appropriate investigation and correct diagnosis. Finally, an understanding of the usual pattern and timing of relapse and knowledge of the typical types of late toxicity expected after successful eradication of the lymphoma allow the patient’s physicians to detect recurrence in a timely fashion and to identify or prevent secondary complications enabling appropriate management plans to be developed. From the Department of Medicine, Division of Medical Oncology, University of British Columbia and the British Columbia Cancer Agency, Vancouver, BC, Canada. Reprints: Joseph M. Connors, MD, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6. E-mail: firstname.lastname@example.org. © 2009 Lippincott Williams & Wilkins, Inc.