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Identifying High-alert Medications in a University Hospital by Applying Data From the Medication Error Reporting System

Tyynismaa, Lotta MScPharm*†; Honkala, Anni MScPharm; Airaksinen, Marja PhD†‡; Shermock, Kenneth PharmD, PhD§; Lehtonen, Lasse MD, PhD

doi: 10.1097/PTS.0000000000000388
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Objectives To facilitate safe use of high-alert medications, lists of medications posing higher risks for medication errors (MEs) and harmful effects have been compiled. These lists can be general or reflect clinical practices in specific settings. Less common has been to compile a hospital-specific list applying data from the organization's ME reporting system. Our objective was to demonstrate a method for compiling such a high-alert medication list in a university hospital.

Methods Of the eighteen 136 MEs reported during 2007 to 2013, ME reports with medications coded as a contributing factor to the incident were included (n = 249). The involved medications were identified and compared with the hospital's drug consumption and Institute for Safe Medication Practice's List of High-Alert Medications. The report narratives of MEs with most reported and high-alert medications (120 reports) were qualitatively content analyzed.

Results The included 249 reports concerned 280 medications, of which 33% were classified as high-alert medications by the Institute for Safe Medication Practice. The most common therapeutic groups were antibacterials for systemic use (13%), psycholeptics (10%), analgesics (9%), and antithrombotic agents (9%). The most common high-alert medications were oxycodone (5%), enoxaparin (3%), and noradrenaline (3%). Serious patient harm (3%) was related to cefuroxime, enoxaparin, ibuprofen, midazolam, propofol, and warfarin. A half of the MEs were related to parenteral preparations. The qualitative content analysis revealed the key process safety risks of the most reported and high-alert medications.

Conclusions The method is applicable for compiling a hospital-specific high-alert medication list and related analysis of key process safety risks contributing to MEs.

From the *HUS-Pharmacy, Hospital Pharmacy of Helsinki University Hospital (HUS); †Specialization Program of Hospital and Health Center Pharmacy, ‡Clinical Pharmacy Group, Faculty of Pharmacy, University of Helsinki, Finland; §Center for Drug Safety and Effectiveness, Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and ∥Department of Public Health, University of Helsinki and Helsinki University Hospital (HUS), Finland.

Correspondence: Lotta Tyynismaa, MScPharm, HUS-Pharmacy, Hospital Pharmacy of Helsinki University Hospital (HUS), and Specialization Program of Hospital and Health Center Pharmacy, Clinical Pharmacy Group, Faculty of Pharmacy, University of Helsinki, Finland (e-mail: lotta.tyynismaa@hus.fi).

The authors disclose no conflict of interest.

L.L. and L.T. received funding from the Finnish Governmental Research Funding (study grant TYH2014224). For the remaining authors, none were declared.

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