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Exploring Relationships Between Hospital Patient Safety Culture and Adverse Events

Mardon, Russell E. PhD; Khanna, Kabir MA; Sorra, Joann PhD; Dyer, Naomi PhD; Famolaro, Theresa MPS

doi: 10.1097/PTS.0b013e3181fd1a00
Original Articles

Objectives: There has been very limited research linking staff perceptions of hospital patient safety culture with rates of adverse clinical events. This exploratory study examined relationships between the Agency for Healthcare Research and Quality's (AHRQ) Hospital Survey of Patient Safety Culture and rates of in-hospital complications and adverse events as measured by the AHRQ Patient Safety Indicators (PSIs). The general hypothesis was that hospitals with a more positive patient safety culture would have lower PSI rates.

Methods: We performed multiple regressions to examine the relationships between 15 patient safety culture variables and a composite measure of adverse clinical events based on 8 risk-adjusted PSIs from 179 hospitals, controlling for hospital bed size and ownership. All patient safety culture data were collected in 2005 and 2006 (except 1 late 2004 hospital), and all PSI data were collected in 2005.

Results: Nearly all of the relationships tested were in the expected direction (negative), and 7 (47%) of the 15 relationships were statistically significant. All significant relationships were of moderate size, with standardized regression coefficients ranging from −0.15 to −0.41, indicating that hospitals with a more positive patient safety culture scores had lower rates of in-hospital complications or adverse events as measured by PSIs.

Conclusions: Our findings support the idea that a more positive patient safety culture is associated with fewer adverse events in hospitals. Further research is needed to determine the generalizability of these results to larger sets of hospitals and to examine the causal relationship between patient safety culture and clinical patient outcomes.

From Westat, Rockville, Maryland.

Correspondence: Russell E. Mardon, PhD, Westat, 1600 Research Blvd, RA 1106, Rockville, MD 20850 (e-mail:

This work was supported by the Agency for Healthcare Research and Quality under contract number: 233-02-0087.

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