Secondary Logo

Institutional members access full text with Ovid®

Predictors of Hypotension Associated With Propofol in Trauma Patients

Shearin, Amanda E. PharmD; Patanwala, Asad E. PharmD; Tang, Andrew MD; Erstad, Brian L. PharmD

doi: 10.1097/JTN.0000000000000022

Propofol use may lead to hypotension in trauma patients intubated in the emergency department. In this study, predictors of hypotension were identified. We hypothesized that demographic variables could be associated with hypotension. Hypotension occurred in 33 of 200 patients. In the multivariate analysis, hypotension was associated with patient age greater than 55 years (odds ratios [OR], 3.61; 95% confidence interval [CI], 1.32-9.86; P = .012), obesity (OR, 2.66; 95% CI, 1.08-6.55; P = .034), and lower baseline blood pressure (OR, 1.59 [per 10-mm Hg decrease]; 95% CI, 1.29-1.96; P = .000). Age greater than 55 years, obesity, and lower baseline systolic blood pressure are associated with a higher risk of propofol-induced hypotension in trauma patients.

Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, Arizona (Drs Shearin, Patanwala, and Erstad); and Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona (Dr Tang).

Correspondence: Asad E. Patanwala, PharmD, 1295 N. Martin, PO Box 210202, Tucson, AZ 85721 (

The authors declare no conflicts of interest.

Copyright © 2014 by the Society of Trauma Nurses.