Many factors impact the success of home infusion therapy. A model has been designed to incorporate all of the factors that need to be considered when setting up a home infusion program. The primary factors included in the model are patient, nursing, medical, caregiver, equipment, environment, medication, and legal issues. Each of the factors are subdivided into relevant points to be included in the patient’s discharge management plan. Using the model will help nurses make a comprehensive patient assessment, plan patient and caregiver education, and assist patients in completing their course of infusion therapy.