Infiltration often is viewed as a natural consequence of routine intravenous therapy. Subcutaneous infiltration of fluid is not always perceived as a serious problem. It is important for the clinician to be aware of the potential for injury as a result of medications or fluid leaking into the tissue. An infiltration is not the natural consequence of infusion therapy. Every effort should be made to ensure that the infusion will be completed safely without complication. The infusion specialist must use good judgment in site determination, device placement, securement, dressing, care, and maintenance.