The prevention and treatment of vesicant extravasation presents unique nursing challenges. In two case studies, the authors describe the clinical response of patients to dimethyl sulfoxide after multivesicant extravasation. The patients studied did not experience deep tissue necrosis or resultant morbidity related to extravasation. Dimethyl sulfoxide has practical applications in the management of vesicant extravasation. However, further research is needed to fully define its role.