No one discounts the cruel nature of the Acquired Immunodeficiency Syndrome epidemic or the pain and devastation left by the virus that brings a lingering death to people in the prime of life. And no one dismisses the horrifying surge in the number of cases over the past decade. In 1981,189 cases of AIDS were reported to the Centers for Disease Control; in 1990, 43,339 cases were reported. Research and technological advances have resulted in advanced treatment modalities aimed at symptomatic treatment of the disease process itself, opportunistic infections associated with the disease, and possibly prevention. These issues are addressed in this update.