2000 Years of Clinical Trials: The Evolution of Evidence-Based Practice : Journal of Christian Nursing

Secondary Logo

Journal Logo

Feature: professional practice/research

2000 Years of Clinical Trials

The Evolution of Evidence-Based Practice

Zrelak, Patricia Ann

Author Information
Journal of Christian Nursing 40(2):p 110-115, April/June 2023. | DOI: 10.1097/CNJ.0000000000001047


Although the first documented clinical trial as described in the biblical book of Daniel dates to 606 BC, the prophet Daniel's nutrition study is contemporary in both approach and topic and could be considered the first comparative effectiveness research (CER) trial. This article summarizes the historical evolution of clinical trials and associated regulatory legislation. Ethical considerations foundational to nursing and evidence-based practice (EBP) in the 21st century are examined. Distinguishing features of CER, various study designs and checklists, and EBP are detailed. Biblical foundations for research and the Bible's relevance to modern research methods are discussed.

InterVarsity Christian Fellowship

You can read the full text of this article if you:

Access through Ovid