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Topiramate Treatment of Alcohol Use Disorder in Clinical Practice

Jefee-Bahloul, Hussam, MD; Jorandby, Lantie, MD; Arias, Albert J., MD, MS

doi: 10.1097/ADM.0000000000000444
Clinical Case Conference

Topiramate is an anticonvulsant medication with increasingly strong evidence, supporting its use for treating alcohol use disorder (AUD) based on clinical trials. These clinical cases summarize the initiation and titration of topiramate in AUD treatment. The core issues of patient selection, consideration of comorbid psychiatric and medical conditions, side-effect profile, safety and effectiveness are reviewed. Addiction physicians should take a leading role in using topiramate to treat AUDs, working with patients to balance the benefits of topiramate with the risk.

University of Massachusetts Medical School, Worcester, MA (HJ-B); Massachusetts General Hospital, Boston, MA (LJ); and Yale University School of Medicine, New Haven, CT (HJ-B, AJA).

Send correspondence to Albert J. Arias, MD, MS, 950 Campbell Rd #116A, West Haven, CT 06516. E-mail:

Received 4 January, 2016

Accepted 11 September, 2016

The authors disclose no conflicts of interest.

© 2019 American Society of Addiction Medicine