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Premenstrual Syndrome and Self-Medication With Opioids

Qurishi, Rouhollah MD; Sonneborn, Christina MD, MRCPsych; de Jong-Arts, Marieke MD; de Jong, Cornelis MD, PhD

doi: 10.1097/ADM.0b013e31827884a3
Case Report

We have described a patient in opioid substitution treatment using heroin to treat her premenstrual complaints. After a short review of the diagnosis and etiology of premenstrual syndrome or premenstrual dysphoric disorder, the relation between premenstrual syndrome/premenstrual dysphoric disorder and opioid receptors is discussed. In the case of the patient described, increasing the dose of methadone in the premenstrual period produced significant clinical improvement.

From the Novadic-Kentron, Network for Addiction Treatment Services, Vught (RQ, CS); Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Center (MJ-A); and Nijmegen Institute for Scientist Practitioners in Addiction, Radboud University Nijmegen (CJ), The Netherlands.

Send correspondence and reprint requests to: Rouhollah Qurishi, Dr Poletlaan 74–76, Post Box No. 2130, 5600 CC Eindhoven, the Netherlands. E-mail:

The authors declare no conflict of interest.

Received March 27, 2012

Accepted October 10, 2012

© 2013 American Society of Addiction Medicine