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Low Risk for Hepatitis C Seroconversion in Methadone Maintenance Treatment

Peles, Einat PhD; Schreiber, Shaul MD; Rados, Vera MD; Adelson, Miriam MD

doi: 10.1097/ADM.0b013e31820e13dd
Original Research

Objectives: To study the risk factors for seroconversion to hepatitis C virus (HCV) infection since admission to methadone maintenance treatment (MMT) and to characterize the seronegative admitted group.

Methods: All 657 patients admitted to our MMT clinic in Tel Aviv, Israel, between 1993 and 2008 were prospectively followed up. Those who were HCV negative (n = 271) with >1 HCV tests (n = 207) were included for seroconversion analyses.

Results: Proportions of ever drug injectors, benzodiazepine abuse, and former USSR immigrants were higher among HCV sera-positive versus sera-negative patients on admission to MMT. The incidence of HCV seroconversion in MMT was 2/100 person years [py] (25 seroconversions, 1133.9 py). Seroconversion rates were higher among 44 younger patients (<30 years: 9.6/100 vs 1.4/100 py, P < 0.0005), among 103 patients with positive urine results to benzodiazepines (3.6/100 vs 1/100 py, P = 0.005), among 118 patients who injected the drugs (3.9/100 vs 1/100 py, P = 0.003), and among 43 patients who dropped out and were readmitted to the MMT (4.3/100 vs 1.7/100 py, P = 0.04). There was a trend of higher seroconversion among 61 females (P = 0.1), among 62 patients with no children (P = 0.1), and among those having hepatitis B antigen (n = 7; P = 0.09). Variables that predicted seroconversion were drug injection, benzodiazepine abuse, and being younger at admission to MMT. Being a former USSR immigrant did not predict seroconversion.

Conclusions: The HCV seroconversion rate of patients in MMT is low, also, for former USSR immigrants. The predictors for seroconversion were only admission variables (younger age at admission to MMT, ever drug injector, and having positive urine to benzodiazepines at MMT admission). Specific intervention to eliminate seroconversion is needed for these high-risk groups.

From the Adelson Clinic for Drug Abuse Treatment & Research, Tel Aviv Sourasky Medical Center and Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel (EP, SS, VR, MA); and Department of Psychiatry (SS), Tel-Aviv Sourasky Medical Center, and Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel.

Send correspondence and reprint requests to Einat Peles, PhD, Adelson Clinic for Drug Abuse, Treatment & Research, Tel-Aviv Sourasky Medical Center, 1 Henrietta Szold Street, Tel Aviv 64924, Israel. E-mail:

The study was funded by The Adelson Family Foundation.

Received July 29, 2010

Accepted January 02, 2011

© 2011 American Society of Addiction Medicine