Laparoscopic Nissen Fundoplication: Clinical Outcomes at 10 Years : Journal of the American College of Surgeons

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Laparoscopic Nissen Fundoplication: Clinical Outcomes at 10 Years

Kelly, Jamie J. BM, FRCS*,†; Watson, David I. MD, FRACS†,*; Chin, Kin Fah BM, FRCS*; Devitt, Peter G. MS, FRCS, FRACS*; Game, Philip A. MBBS, FRCS, FRACS*; Jamieson, Glyn G. MS, FRACS*

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Journal of the American College of Surgeons 205(4):p 570-575, October 2007. | DOI: 10.1016/j.jamcollsurg.2007.05.024



Laparoscopic Nissen fundoplication is now the most common operative procedure for treatment of gastroesophageal reflux disease, although longterm clinical outcomes after this procedure remain uncertain.


Outcomes for 250 patients who underwent Nissen (total) fundoplication at least 10 years ago (September 1991 to August 1995) were determined prospectively using a structured questionnaire that evaluated clinical symptom scores for heartburn, dysphagia, and satisfaction with clinical outcomes.


Clinical followup data for at least 10 years (120 to 167 months) after operation were available for 226 patients, an additional 21 patients had died, making outcomes for 247 patients (99%). Of the three (1%) remaining patients, one was lost to followup and dementia developed in two. One hundred eighty-seven (83%) patients were highly satisfied with the clinical outcomes. One hundred eighty-nine (84%) had good or excellent control of heartburn. Symptom scores for heartburn, dysphagia, and overall satisfaction were unchanged from 5-year followup data. Forty-two (17%) patients underwent revision operations, 28 (22%) were in the first 125 patients and 14 (11%) in the subsequent 125 patients. Antireflux medication use increased gradually, resulting in 47 (21%) patients using medication at 10 years. Of 21 deaths, 1 was postoperative and the remaining 20 were similar to that predicted for a matched population. A high preoperative heartburn score correlated with high patient satisfaction and lower dysphagia score at 10 or more years (p = 0.038 and p = 0.041, respectively).


Laparoscopic Nissen fundoplication is an effective longterm treatment for gastroesophageal reflux disease.

© 2007 by Lippincott Williams & Wilkins, Inc.

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