From the Departments of Surgical Oncology (Chun, Nishioka, Arvide, Vauthey), University of Texas MD Anderson Cancer Center, Houston, TX
Pathology (Katkhuda, Maru), University of Texas MD Anderson Cancer Center, Houston, TX
Gastrointestinal Medical Oncology (Kopetz), University of Texas MD Anderson Cancer Center, Houston, TX
the Departments of Digestive Surgery (Passot), Lyon Sud University Hospital, Hospices Civils de Lyon, Lyon, France.
Pathology (Benzerdjeb), Lyon Sud University Hospital, Hospices Civils de Lyon, Lyon, France.
Biochemistry and Molecular Biology (Lopez), Lyon Sud University Hospital, Hospices Civils de Lyon, Lyon, France.
Received January 8, 2022; Revised March 21, 2022; Accepted March 23, 2022.
CME questions for this article available at http://jacscme.facs.org
Disclosure Information: Authors have nothing to disclose. Timothy J Eberlein, Editor-in-Chief, has nothing to disclose. Ronald J Weigel, CME Editor, has nothing to disclose.
Disclosures outside the scope of this work: Dr Kopetz owns stock in MolecularMatch, Lutris, and Frontier Medicines; is a paid consultant to Genentech, EMD Serono, Merck, Holy Stone, Novartis, Lilly, Boehringer Ingelheim, Boston Biomedical, AstraZeneca/MedImmune, Bayer Health, Pierre Fabre, Redx Pharma, Ipsen, Daiichi Sankyo, Natera, HalioDx, Jacobio, Pfizer, Repare Therapeutics, Inivata, GlaxoSmithKline, Jazz Pharmaceuticals, Iylon, Xilis, Abbvie, Amal Therapeutics, Gilead Sciences, Mirati Therapeutics, Flame Biosciences, Servier, Carina Biotechnology, Bicara Therapeutics, Endeavor BioMedicines, Numab Pharma, Johnson & Johnson/Janssen, Genomic Health, Replimune, Taiho Pharmaceutical, Cardiff Oncology, Ono Pharmaceutical, Bristol Meyers Squibb/Medarex, Amgen, and Tempus; and receives research funding from Sanofi, Biocartis, Guardant Health, Array BioPharma, Genentech/Roche, EMD Serono, MedImmune, Novartis, Amgen, Lilly, and Daiichi Sankyo. Other authors have nothing to disclose.
Support: This work was supported by NIH grants (T32 CA 009599 and P30 CA016672) and the International Hepato-Pancreato-Biliary Association (Kenneth Warren Fellowship).
Presented at the Western Surgical Association 129th Scientific Session, Indian Wells, CA, November 2021.
A discussion of this article is available at https://links.lww.com/JACS/A70.
Correspondence address: Jean-Nicolas Vauthey, MD, FACS, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1484, Houston, TX 77030. email: [email protected]
