Large bone defects caused by traumatic open fractures are complex and can overwhelm both the patient and the surgeon who together must make a large series of decisions on a lengthy reconstructive pathway. The purpose of this article is to review the sequence of decision making for these difficult injuries. Specifically, this article will address: (1) initial debridement; (2) subsequent debridements and medical management; and (3) definitive reconstruction.
Management of the Bony Injury
How Much to Debride?
Although open fractures are common and frequently studied, it remains true that surgical principles, rather than evidence based medicine, continue to guide open fracture debridement. Even contemporary investigations simply state that open fractures should be debrided until “stable” and “all necrotic tissue and organic and inorganic contaminants have been removed.”1 Unfortunately, quantifying debridement beyond these subjective descriptions remains illusive.
A frequent, specific scenario relevant to the topic of critical-sized bone defects is the large bone fragment that remains in the wound and is devoid of soft tissue attachments. Although retaining this fragment may risk infection and has led authors to recommend radical debridement,2 removing such a fragment undoubtedly worsens the reconstructive challenge. The decision of whether to retain or remove a major bony fragment requires weighing the risks and benefits.
The surgeon must first determine the value of the specific bone fragment. On 1 end of the spectrum, there is the low value fragment, such as a moderate-sized diaphyseal fragment, which can be managed easily with contemporary techniques. At the other extreme is the high value fragment, such as a large osteochondral fragment or whole extruded bone that is essentially irreplaceable.
When considering the low value diaphyseal fragment, the current practice is to remove this fragment.3 Although direct comparisons of retention versus debridement of such fragments is lacking, it is generally accepted that devascularized fragments can serve as a nidus for infection. Although removal of such fragments often requires later procedures to achieve union, excision seems to be a justifiable step because the treatment of a critical-sized defect is preferable to the management of established osteomyelitis.
The same cannot be said for large osteochondral fragments. Large sections of articular surface, once removed, allow for limited reconstructive options: allograft replacement, primary arthroplasty, or joint fusion. In such a scenario, cleaning and retaining such a fragment becomes a reasonable option. An extruded talus represents a dramatic example of such a fragment. Short of reimplantation, there is nothing a surgeon can do to re-establish normal anatomic relationships from this injury, and multiple authors have reported limited success with debridement and retention.4–14 Other authors also have reported on the successful treatment of open fractures with cleansing and replantation of devitalized bone fragments.15–17 Thus, for high value, irreplaceable fragments, debridement, and reimplantation remains a reasonable option.
External Fixation or Early Definitive Fixation?
Once the debridement is complete, the bone injury requires some form of stabilization. Outside of the need for damage control orthopedics and certain periarticular fractures, surgeons must decide between immediate definitive fixation and initial external fixation with later staged reconstruction. Immediate definitive fixation is attractive because it eliminates the need for subsequent staged internal fixation. The primary argument for external fixation is it avoids the placement of definitive implants in a potentially contaminated wound beds.
Brumback et al evaluated the treatment of open femur fractures using immediate definitive hardware placement, specifically an intramedullary nail.18 In this series, none of the 62 type I, II, or IIIA injuries were complicated by infection. Results did worsen for IIIB injuries, where 3 of 27 patients developed an infection.
Tornetta et al compared immediate intramedullary nailing to definitive external fixation for 29 type IIIB tibia fractures.19 All patients went on to union and 1 in each group experienced a deep infection. Similarly, Henley et al evaluated the treatment of 174 type II, IIIA, and IIIB open tibia fractures treated with immediate intramedullary nail or definitive external fixation.20 Although more severe injuries predicted higher infection and nonunion rates, the choice of an immediate intramedullary nail did not seem to significantly increase infection rates. Both reports noted the relative ease of caring for patients with internal fixation versus external fixation. Although neither report directly compared immediate definitive fixation with external fixation and staged definitive fixation, higher rates of infection were not seen with initial definitive fixation in these series, suggesting that immediate internal fixation after a thorough irrigation and debridement may be reasonable.
In summary, immediate definitive fixation, particularly with an intramedullary device, seems safe and justified in lower grade injuries (types I, II, and IIIA). Infection rates are higher for type IIIB and IIIC injuries and clinical judgment is still necessary in the selection between immediate internal fixation and staged fixation after initial external fixation.3
Management of the Soft Tissue Injury
Should the Wound Be Closed?
Classic surgical principles dictate that infected and traumatic wounds be left open to avoid the containment of sepsis, and indeed open fracture wounds were often left open even if closeable in past decades.21–24 More recent evidence, however, seems to firmly suggest the benefit of immediate closure for type I, II, and IIIA open fractures. Jenkinson et al, examining 146 patients with open lower extremity fractures, reported an infection rate of 4.1% in wounds that were primarily closed versus 17.8% that underwent delayed closure.25
What to Apply to a Wound That Cannot Be Closed?
When the presenting wounds and their surgical extensions cannot be closed during the initial procedure, the surgeon must then decide how to cover the wound. Most of the early studies of open fractures suggested that such wounds be left completely or partially open after the initial debridement.21–24 Subsequent studies, however, suggested that allowing nosocomial infections into open wounds, rather than containing initial inoculums from the time of injury, may be the greater concern. In a study that examined 21 type IIIB open fractures that became infected, 57% of local sepsis was caused by organisms not present in the wounds during the first 2 weeks of treatment.26 Traditional “wet-to-dry” dressings have given way to negative pressure wound therapy (NPWT). Multiple authors have now shown a dramatic reduction in infection rates with the use of NPWT (5%–8%) compared with gauze dressings (∼28%).27,28 Similarly, other authors have shown both reduction in gram-negative infection rates29 and polymicrobial infections with NPWT.30
Subsequent Debridements and Medical Management
Are More Debridements Necessary? When Is the Wound Clean?
Despite major advances in the care of severe lower extremity trauma in the last several decades, there is surprisingly little more than clinical judgment to help surgeons decide when a wound is “clean.” Although open wound cultures initially were felt to be useful as a guide for further debridements and appropriate antibiotic selection, these cultures have not been shown to successfully predict later infection or an infecting organism.31–33 An on-going multicenter study (Bioburden) by the Major Extremity Trauma Research Consortium (METRC) is evaluating the utility of using polymerase chain reaction techniques to characterize wound contamination/colonization at the time of wound closure in severe lower extremity injury.1 This investigation may provide some much needed insight into objectively determining the health of traumatic wounds. Pending these results and further investigation, existing surgical principles still dictate management: all wounds should be debrided to stable, clean appearing margins, which may require multiple returns to the operating room depending on the visual evolution of the wound over time.
How Are Antibiotics Managed From Initial Presentation to Definitive Fixation?
Prompt administration of antibiotics in open fracture management has been shown to have clear benefit. Early publications from Patzakis, Gustillo, and Anderson clearly demonstrated the dramatic reduction in infection rates with the use of antibiotics and the necessity for gram-negative coverage in type III open fractures.23,34,35 Since that time, investigators have emphasized the importance of administering antibiotics early after injury. Infection rates have been shown to rise from 7% to 28% in those patients who received antibiotics within 60 minutes compared with those who received antibiotics 90 minutes or later after injury.36
The specific of which antibiotics to use is less clear. Traditionally, a first generation cephalosporin has been recommended for type I and II open fractures and gentamicin has been added to type III injuries.23,35 With the aim of avoiding some of the complications of aminoglycocides, more recent studies have explored the use of alternative gram-negative coverage. Ceftriaxone,37 piperacillin/tazobactam,38 cefotaxime,39 and cefepime40 have all been investigated and been found to be either superior or no less effective. The addition of penicillin for fecal or potential clostridial contamination is also recommended.41
A final consideration is the duration of antibiotics and their relationship to closure or coverage of any open wounds. Current Eastern Association for the Surgery of Trauma (EAST) Guidelines (Luchette, Hoff) recommend the administration of antibiotics for 24 hours after the treatment of type I and II fractures.42,43 This suggestion is supported by work that demonstrates no difference in infection rates between 1 and 5 days of antibiotic coverage.44 For type III open injuries, EAST recommends extending coverage for up to 72 hours or 24 hours after definitive closure or coverage.42,43
Management of the Bone Injury
Induced Membranes Technique Versus Bone Transport?
The primary contemporary means of reconstructing critical bone defects are the induced membranes technique, pioneered by Masquelet, and distraction osteogenesis (DO), introduced by Ilizarov. Induced membrane technique (IMT) places a cement spacer in a defect, allows the formation of a membrane around it over the course of 6 weeks, and then requires a secondary surgery to remove the spacer and place autograft into the membrane-surrounded defect. DO generates the new bone away from a defect at the site of a remote corticotomy; the bone fragment between the corticotomy and the original critical defect is moved slowly to simultaneously narrow the critical defect and generate new bone in the growing corticotomy site.
The results of both IMT and DO are well summarized in recent meta-analyses. Morelli at al analyzed 17 studies (427 patients) looking at the results of IMT.45 The mean size of the defects in this review was 5.5 cm, with 21% being >10 cm. Complication rates were near 50%, with new infection (∼10%), persistent infection, or nonunion (18%), and the need for further surgery (∼36%) all being common. Despite this, the ultimate union rate at 15 months reached almost 90%.
Papakostidis similarly analyzed the results of DO, citing 37 articles (898 patients) with patients with a mean defect between 3.5 and 11.1 cm.46 Complications were again common with infection ranging from 0% to 60% for tibias and 0%–6.2% for femurs, and refracture ranging from 0% to 19% in tibias and 3.3%–7.7% in femurs. However, like IMT, eventual union rates were high, with rates of 94% in tibias and 96% in femurs.
No direct comparisons of IMT and DO exist to suggest which is preferable in a particular patient. Given the heterogeneity of patients and these injuries, it is unlikely that 1 approach is truly superior to the other. Relatively small defects, defects that are not circumferential, and defects that exist in the presence of stable internal fixation may be better managed with IMT. By contrast, a large bone defect also associated with existing or previous infection or soft tissue loss might be better managed with DO. The need for exceptional patient compliance with fixator lengthening and hygiene, however, may make DO a less attractive option in some patients.
Management of the Soft Tissue Injury
Timing of Soft Tissue Coverage?
Multiple previous authors have attempted to determine whether a correlation exists between the timing of definitive flap coverage and patient outcomes. The Lower Extremity Assessment Project (LEAP) group, in 2 separate publications, failed to demonstrate the timing of flap coverage as an influence on complication rates.47,48 These authors used 72 hours as the distinction between early and late coverage. Later, authors, using a single institution database and 7 days as the inflection point, were able to demonstrate the influence of timing on the rates of flap complications.49 Although no difference in complication rates was noted for days 1–7, each day after 7 days resulted in an 11% increase rate of complications and 16% increased risk of infection specifically. As such, current evidence seems to suggest an aggressive approach for coverage of 3B open wounds.
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