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Delay in Flap Coverage Past 7 Days Increases Complications for Open Tibia Fractures

A Cohort Study of 140 North American Trauma Centers

Pincus, Daniel, MD*,†,‡; Byrne, James P., MD†,‡,§; Nathens, Avery B., MD, MPH, PhD*,†,‡,§; Miller, Anna N., MD; Wolinsky, Philip R., MD; Wasserstein, David, MD, MSc, MPH*,§; Ravi, Bheeshma, MD, PhD*,§; Jenkinson, Richard J., MD, MSc*,§

Journal of Orthopaedic Trauma: April 2019 - Volume 33 - Issue 4 - p 161–168
doi: 10.1097/BOT.0000000000001434
Original Article
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Objectives: To measure time to flap coverage after open tibia fractures and assess whether delays are associated with inpatient complications.

Design: Retrospective cohort study.

Setting: One forty level I and II trauma centers in Canada and the United States.

Patients/Participants: Adult patients (≥16 years) undergoing surgery for (1) an open tibia (including ankle) fracture and (2) a soft-tissue flap during their index admission between January 1, 2012, and December 31, 2015, were eligible for inclusion.

Exposure: Time from hospital arrival to definitive flap coverage (in days).

Main outcome measurements: The primary outcome was a composite of the following complications occurring during the index admission: (1) deep infection, (2) osteomyelitis, and/or (3) amputation. The primary analysis compared complications between early and delayed coverage groups (≤7 and >7 days, respectively) after matching on propensity scores. We also used logistic regression with time to flap coverage as a continuous variable to examine the impact of the duration of delay on complications.

Results: There were 672 patients at 140 centers included. Of these, 412 (61.3%) had delayed coverage (>7 days). Delayed coverage was associated with a significant increase in complications during the index admission after matching (16.7% vs. 6.2%, P < 0.001, number needed to harm = 10). Each additional week of delay was associated with an approximate 40% increased adjusted risk of complications (adjusted odds ratio 1.44, 95% confidence interval 1.13–1.82, for each week coverage was delayed, P = 0.003).

Conclusion: This is the first multicenter study of flap coverage for tibia fractures in North America. Complications rose significantly when flap coverage was delayed beyond 7 days, consistent with current guideline recommendations. Because the majority of patients did not have coverage within this timeframe, initiatives are required to improve care for patients with these injuries.

Level of Evidence: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

*Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada;

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada;

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada;

§Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Canada;

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO; and

University of California Davis Orthopedics.

Reprints: Daniel Pincus, MD, Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, 149 College St, Room 508-A, Toronto, ON M5T 1P5, Canada (e-mail: d.pincus@utoronto.ca).

A. B. Nathens is the Director of the ACS Trauma Quality Improvement Program. The remaining authors report no conflict of interest.

Presented in part at the Annual Meeting of the Orthopaedic Trauma Association, October 14, 2017, Vancouver, BC, Canada.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jorthotrauma.com).

Accepted December 27, 2018

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