Review ArticleGrowth Factors: Beyond Bone Morphogenetic ProteinsNauth, Aaron MD, FRCSC*¶; Giannoudis, Peter V MD†; Einhorn, Thomas A MD‡; Hankenson, Kurt D DVM, PhD§; Friedlaender, Gary E MD‖; Li, Ru MD, PhD¶; Schemitsch, Emil H MD, FRCSC*¶Author Information From the *Department of Surgery, Division of Orthopaedics, St. Michael's Hospital, University of Toronto, Toronto, Canada; †Department of Trauma and Orthopaedic Surgery, University of Leeds, Leeds, UK; ‡Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA; §Department of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA; ‖Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT; and ¶Musculoskeletal Research Laboratory, St. Michael's Hospital, Toronto, Canada. Accepted for publication June 10, 2010. No funds were received in support of this work. One or more of the authors have received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article. Reprints: Emil H. Schemitsch, MD, FRCSC, St. Michael's Hospital, 55 Queens Street East, Suite 800, Toronto, Ontario, Canada, M5C 1R6 (e-mail: SchemitschE@smh.ca). Journal of Orthopaedic Trauma: September 2010 - Volume 24 - Issue 9 - p 543-546 doi: 10.1097/BOT.0b013e3181ec4833 Buy Metrics Abstract The current landscape of growth factors in orthopaedic trauma is dominated by the BMPs, as they are the most extensively studied growth factors in clinical applications pertaining to orthopaedic trauma. Despite this, their application and indications for use in trauma remain controversial. This article highlights a number of selected growth factors, other than BMPs, that are currently being investigated in orthopaedic trauma applications. These growth factors have shown significant promise in preclinical and early clinical investigation. © 2010 Lippincott Williams & Wilkins, Inc.