Review ArticleBasic Science of Intra-articular Fractures and Posttraumatic OsteoarthritisMcKinley, Todd O MD*; Borrelli, Joseph Jr MD†; D'Lima, Darryl D MD, PhD‡; Furman, Bridgette D BS§; Giannoudis, Peter V MD, FRCS‖Author Information From the *Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA; †University of Texas Southwestern, Dallas, TX; ‡Scripps Research Institute La Jolla, CA; §Duke University Durham, NC; and ∥University of Leeds, Leeds, UK. Accepted for publication June 16, 2010. This work has been funded by the following grants: National Institute of Arthritis and Musculoskeletal and Skin Diseases 1RC2AR058954-01; National Institutes of Health (NIH) P50 AR055533; and NIH AR50245. Reprints: Todd O. McKinley, MD, Professor, Department of Orthopaedic Surgery, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242 (e-mail: [email protected]). Journal of Orthopaedic Trauma: September 2010 - Volume 24 - Issue 9 - p 567-570 doi: 10.1097/BOT.0b013e3181ed298d Buy Metrics Abstract Intra-articular fractures represent the primary etiologic factor leading to posttraumatic osteoarthritis. The pathomechanisms linking intra-articular fractures to end-stage cartilage destruction are poorly understood. However, fracture-related chondrocyte death has been linked to posttraumatic osteoarthritis. Researchers have made significant progress in understanding the pathomechanical link between injury and chondrocyte death. This article reviews recent basic scientific progress investigating intraarticular fractures and fracture-related chondrocyte death and dysfunction. © 2010 Lippincott Williams & Wilkins, Inc.