COVIDImpact of the COVID-19 Pandemic on the Short-Term Course of Obsessive-Compulsive DisorderSharma, Lavanya P. MD∗; Balachander, Srinivas MD∗; Thamby, Abel MD∗; Bhattacharya, Mahashweta MPhil†; Kishore, Chethana MD∗; Shanbhag, Vandita MD∗; Sekharan, Jaisoorya T. MD∗; Narayanaswamy, Janardhanan C. MD∗; Arumugham, Shyam Sundar MD∗; Reddy, Janardhan Y.C. MD∗Author Information ∗Obsessive-Compulsive Disorder Clinic, Department of Psychiatry †Department of Clinical Psychology, National Institute of Mental Health & Neurosciences, Bangalore, India. Send reprint requests to Janardhan Y.C. Reddy, MD, Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Hombegowda Nagar, Bangalore, Karnataka 560029, India. E-mail: [email protected]. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.jonmd.com). The Journal of Nervous and Mental Disease: April 2021 - Volume 209 - Issue 4 - p 256-264 doi: 10.1097/NMD.0000000000001318 Buy SDC Metrics Abstract There is an understandable concern that obsessive-compulsive disorder (OCD) may worsen during the COVID-19 pandemic, but there are little empirical data. We report the impact of COVID-19 pandemic on the short-term course of OCD. A cohort of patients with a primary diagnosis of OCD (n = 240) who were on regular follow-up at a tertiary care specialty OCD clinic in India were assessed telephonically, about 2 months after the declaration of the pandemic (“pandemic” cohort). Data from the medical records of an independent set of patients with OCD (n = 207) who were followed up during the same period, 1 year prior, was used for comparison (historical controls). The pandemic group and historical controls did not differ in the trajectories of the Yale-Brown Obsessive-Compulsive Scale scores (chi-square likelihood ratio test of the group × time interaction = 2.73, p = 0.255) and relapse rate (21% vs. 20%; adjusted odds ratio, 0.81; 95% confidence interval, 0.41–1.59; p = 0.535). Preexisting contamination symptoms and COVID-19–related health anxiety measured by the COVID-Threat Scale did not predict relapse. Only a small proportion of patients (6%) reported COVID-19–themed obsessive-compulsive symptoms. The COVID-19 pandemic, at least in the short run, did not influence the course of illness. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.