Original ArticlesUnintended Deviations of a Random Event Generator by Patients With Late Life Depression and Anxiety During a Direct Mental Influence TaskKadler, Grace HrBSc∗; Vasudev, Akshya MD†,‡; Ionson, Emily HrBSc†,‡; Barušs, Imants PhD§ Author Information ∗Faculty of Medical Science, Western University †Geriatric Mental Health Program, London Health Sciences Centre ‡Integrative Psychiatry Lab at Western University §Department of Psychology, King's University College at Western University, London, ON, Canada. Send reprint requests to Imants Barušs, PhD, Department of Psychology, King's University College at Western University, 266 Epworth Ave, London, ON, Canada, N6A 2M3. E-mail: [email protected]. The present study was approved by Western University’s Research Ethics Board, Lawson Health Research Institute, and King’s University College at Western University’s Research Ethics Review Committee. All participants gave informed consent and the experiment was conducted in accordance to acceptable research standards. The Journal of Nervous and Mental Disease 210(4):p 282-289, April 2022. | DOI: 10.1097/NMD.0000000000001443 Buy Metrics Abstract The primary objective was to determine whether depression and anxiety influence the outcome of random microevents in a nonrandom manner in the absence of any physical intervention by using a random event generator (REG). The secondary objective was to correlate other dimensions of consciousness with the REG's output. The experimental group (n = 30) included individuals with depression, the control group (n = 15) included individuals without depression, and the comparison group (n = 10) included individuals with or without depression. It was hypothesized that those with depression or anxiety would significantly deviate the REG in the unintended direction but the whole sample did [t(49) = −2.37, p = 0.022, two tailed]. There was no significant difference between the group means [F(2, 50) = 0.12, p = 0.84] and no robust correlations between dimensions of consciousness and REG activity. Further analysis is needed to understand negative emotions in mind-matter interactions. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.