Review ArticleSchizophrenia and Dental Health A Systematic ReviewComparelli, Anna MD, PhD∗; Stampatore, Lorenzo MD†; Costacurta, Micaela PhD‡; Pompili, Maurizio MD, PhD∗,†Author Information ∗Azienda Ospedaliero–Universitaria Sant'Andrea †Nesmos, Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome ‡Department of Surgical Science, University of Rome Tor Vergata, Rome, Italy. Send reprint requests to Anna Comparelli, MD, PhD, Azienda Ospedaliero–Universitaria Sant'Andrea, Via di Grottarossa 1035-1039, Rome 00198, Italy. E-mail: [email protected]. The Journal of Nervous and Mental Disease: September 2021 - Volume 209 - Issue 9 - p 684-690 doi: 10.1097/NMD.0000000000001371 Buy Metrics Abstract Schizophrenia is characterized not only by psychopathological symptoms but also by medical comorbidities. Among the latter, there are limited data on dental health. We conducted a systematic review with the primary aim of clarifying the extent of the relationship between dental diseases and schizophrenia. The second aim was to delineate an intervention program based on illness-related factors that influence dental health. The preferred reporting items for systematic reviews and meta-analyses statement for reporting systematic reviews was used. Only articles published in English language peer-reviewed journals were considered; we excluded case reports, meta-analyses, and systematic reviews, as well as studies that did not clearly report statistical analysis, diagnostic criteria, or the number of patients included. Twenty-one studies comprising 13,110 patients with schizophrenia and 9025 healthy controls were included. Negative symptomatology, long duration of illness, smoking habit, drug-induced xerostomia, and neuroinflammation are the most critical areas. We suggest an intervention program for prevention and treatment of dental diseases in schizophrenia. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.