Original ArticlesSpecific Phobia Risk Factor of Other Psychiatric DisordersWetzer, Guido MD∗,†; ten Have, Margreet PhD‡; de Graaf, Ron PhD‡; Batelaan, Neeltje M. MD, PhD∗,†; van Balkom, Anton J.L.M. MD, PhD∗,† Author Information ∗Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute †GGZ inGeest Specialized Mental Health Care, Amsterdam ‡Netherlands Institute of Mental Health and Addiction (Trimbos Institute), Utrecht, the Netherlands. Send reprint requests to Anton J.L.M. van Balkom, MD, PhD, Department of Psychiatry, VU University Medical Center and GGZ inGeest, Oldenaller 1, 1081 HJ Amsterdam, the Netherlands. E-mail: [email protected]. The Journal of Nervous and Mental Disease: July 2021 - Volume 209 - Issue 7 - p 484-490 doi: 10.1097/NMD.0000000000001341 Buy Metrics Abstract Predicting the onset and persistence of psychopathology and limited functioning might enable personalized care. Specific phobia (SP) might serve as a predictor, but this needs further evaluation. Participants of the Netherlands Mental Health Survey and Incidence Study-2 were divided into three groups: no-SP (n = 6094), history of SP (n = 204), and current SP (n = 348). Results showed that current SP was associated with a higher prevalence of other anxiety disorders, mood and substance use disorders, and lower levels of functioning. The 6-year onset of other anxiety disorders was associated with history and current SP. Current-SP was also associated with the onset of mood disorders. Neuroticism and childhood trauma only partly accounted for these associations. To conclude, SP was independently associated with presence and onset of other disorders and with limited functioning over time. The presence of SP may serve as an identifier of persons vulnerable to the development of other psychopathologies. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.