Review ArticlesCOVID-19 and Suicide A Deadly AssociationAbi Zeid Daou, Margarita MD∗,†; Rached, Gaelle MD‡; Geller, Jeffrey MD, MPH∗ Author Information ∗Department of Psychiatry, University of Massachusetts Medical School †Worcester Recovery Center and Hospital, Worcester, Massachusetts ‡Faculty of Medicine, University of Saint Joseph of Beirut, Beirut, Lebanon. Send reprint requests to Margarita Abi Zeid Daou, MD, Department of Psychiatry, University of Massachusetts Medical School, 309 Belmont Street, K3A1, Worcester, MA 02128. E-mail: [email protected]. The Journal of Nervous and Mental Disease: May 2021 - Volume 209 - Issue 5 - p 311-319 doi: 10.1097/NMD.0000000000001338 Buy Metrics Abstract COVID-19 hit the world amidst an unprecedented suicide epidemic in this century. As the world focuses on limiting the spread of the virus and prioritizing acutely medically ill patients, containment measures are not without mental health consequences. With rising anxiety and depression, risk of suicide—acutely and in the aftermath of the pandemic—also rises. This article aims to shed light on this major public health problem and better understand what factors may create or exacerbate psychiatric symptoms and suicide. We review suicide data predating the pandemic and examine impact of previous epidemics on suicide rates. We then focus on the current pandemic's impacts and the world's response to COVID-19. We examine how these may lead to increased suicide rates, focusing on the US population. Finally, we offer suggestions on mitigating interventions to curb the impending rise in suicide and the resultant increased burden on an already stretched health care system. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.