Original ArticlesCognitive Remediation for Inpatients With Schizophrenia Effects of a Brief and Intensive TrainingBuonocore, Mariachiara PsyD∗; Agostoni, Giulia PsyD∗; Bechi, Margherita PsyD∗; Inguscio, Emanuela PsyD†; Gritti, Davide PsyD†; Anchora, Lavinia PsyD†; Spangaro, Marco MD∗; Cocchi, Federica MD∗; Bianchi, Laura MD∗; Guglielmino, Carmelo MD∗; Sormani, Marika HE∗; Russotti, Massimiliano HE∗; Bosia, Marta MD, PhD∗,‡; Cavallaro, Roberto MD∗,‡Author Information ∗Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute †School of Psychology ‡School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. Send reprint requests to Marta Bosia, MD, PhD, Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, 20127 Milano, Italy. E-mail: [email protected]. The Journal of Nervous and Mental Disease: January 2021 - Volume 209 - Issue 1 - p 76-81 doi: 10.1097/NMD.0000000000001262 Buy Metrics Abstract Computer-assisted cognitive remediation (CACR) is a computer-based rehabilitation treatment aimed at improving cognition and at developing strategies that can be applied to various functional areas. Different protocols are currently used with great variability over the intensity and duration of treatments. In this study, we evaluated the effects of a brief and intensive CACR training (i.e., 15 sessions for 3 weeks) on cognitive domains, as well as the durability of cognitive gains and their generalization to functional areas, 3 months after CACR training. Thirty-eight patients with schizophrenia were recruited and assessed for psychopathology, cognitive performance, and functioning before the rehabilitative intervention. Patients were reassessed for cognition after CACR rehabilitation. Moreover, a subsample of 13 patients was evaluated for cognition and functioning 3 months after CACR completion. Results show significant improvements in multiple cognitive domains after CACR. Furthermore, 3 months after CACR completion, significant improvements were also detected in executive functions and daily functioning. This study suggests that a brief and intense CACR training is effective on cognitive and functional domains and that it could be feasible and affordable for health care services, thus offering patients the best options for fulfilling recovery goals. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.