Original ArticlesAdjuvant Guided Exercise Therapy Versus Self-Organized Activity in Patients With Major DepressionHaussleiter, Ida S. MD∗,†; Bolsinger, Brigitta MA∗; Assion, Hans-Jörg MD, PhD‡; Juckel, Georg MD, PhD∗,† Author Information ∗Department of Psychiatry †Institute of Mental Health, LWL University Hospital Bochum, Bochum ‡LWL Hospital Dortmund, Dortmund, Germany. Send reprint requests to Georg Juckel, MD, PhD, Department of Psychiatry, LWL University Hospital Bochum, Alexandrinenstr. 1, 44791 Bochum, Germany. E-mail: [email protected]. Data availability statement: Data are available on request. The Journal of Nervous and Mental Disease: December 2020 - Volume 208 - Issue 12 - p 982-988 doi: 10.1097/NMD.0000000000001240 Buy Metrics Abstract Exercise seems to be effective in reducing depression itself, as well as the risk of relapse. This study evaluated whether standardized guided exercise therapy (GET) in comparison with self-organized activity (SOA) is an effective augmentation therapy in depressive adults. A total of 111 inpatients (66.7% women; mean age, 45.05 ± 12.19 years) with major depression were randomly assigned to either GET or SOA. Interventions were performed three times a week, with each session lasting 50 minutes. Both GET and SOA exerted effects even after a short-term application of 6 weeks. GET was superior to SOA in reducing depression symptom severity, as measured by the Hamilton Depression Scale (p = 0.017), specifically improving suicidality (p = 0.028) as well as time (p = 0.003) and severity of diurnal variation (p = 0.027). The findings support the beneficial role of adjuvant GET in patients with major depression as a feasible treatment in a psychiatric short-term inpatient setting. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.