Original ArticlesWell-Being and Self-Disorders in Schizotypal Disorder and Asperger Syndrome/Autism Spectrum DisorderNilsson, Maria MD, PhD*,†; Handest, Peter PhD‡; Carlsson, Jessica PhD*,†,§; Nylander, Lena PhD∥,¶; Pedersen, Lennart MSc#; Mortensen, Erik Lykke MSc**; Arnfred, Sidse MD, DMSc†,††Author Information *Mental Health Centre Ballerup, Ballerup †Department of Clinical Medicine, University of Copenhagen, Copenhagen ‡Institute for Mental Health, Herlev §Competence Centre for Transcultural Psychiatry, Ballerup, Denmark ∥Department of Clinical Sciences/Psychiatry, Lund University, Lund ¶Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden #Center for Autism, Herlev **Department of Public Health and Center for Healthy Aging, University of Copenhagen, Copenhagen ††Psychiatry West, Slagelse, Region Zealand Mental Health Service, Slagelse, Denmark. Send reprint requests to Maria Nilsson, MD, PhD, Mental Health Centre Ballerup, Building 14, Maglevænget 2, 2750 Ballerup, Denmark. E-mail: firstname.lastname@example.org. The Journal of Nervous and Mental Disease: May 2020 - Volume 208 - Issue 5 - p 418-423 doi: 10.1097/NMD.0000000000001145 Buy Metrics Abstract We explored subjective well-being in two groups of young adult participants diagnosed with either schizotypal disorder (Sd) (n = 29) or Asperger syndrome/autism spectrum disorder (As/ASD) (n = 22). Well-being was impaired in both groups and was lower in the Sd group than in the As/ASD group. Furthermore, there was a negative correlation between well-being and the presence of self-disorders. The negative effect of self-disorders on well-being was still significant when adjusted for diagnosis, age and gender, and level of function. The present findings point toward clinically important disorder-specific differences in the nature of impaired well-being between the Sd group and the As/ASD group, as there seems to be a self-disorder–driven additional contribution to impaired subjective well-being within the schizophrenia spectrum. These findings further nuance the understanding of fundamental and clinically important qualitative differences between the schizophrenia spectrum and the autism spectrum. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.