Original ArticlesToxoplasmosis in a Cohort of Italian Patients With Bipolar and Psychotic Disorders How Infection May Affect Clinical Features?Del Grande, Claudia MD*; Schiavi, Elisa MD*; Masci, Isabella MD*; Barbuti, Margherita MD*; Maccariello, Giuseppe MD*; Massimetti, Gabriele Dr Sci*; Bruschi, Fabrizio MD†; Dell'Osso, Liliana MD, PhD*Author Information *Section of Psychiatry, Department of Clinical and Experimental Medicine †Department of Translational Research, N.T.M.S., School of Medicine, University of Pisa, Pisa, Italy. Send reprint requests to Fabrizio Bruschi, MD, Department of Translational Research, N.T.M.S., School of Medicine, University of Pisa, Via Roma 55, 56126 Pisa, Italy. E-mail: email@example.com. Online date: November 19, 2019 The Journal of Nervous and Mental Disease: February 2020 - Volume 208 - Issue 2 - p 118-126 doi: 10.1097/NMD.0000000000001102 Buy Metrics Abstract This study investigated the seroprevalence of Toxoplasma gondii in a cohort of 101 Italian inpatients affected by mood or schizophrenia-spectrum disorders and compared clinical features between seronegative and seropositive subjects. Patients diagnosed according to DSM-5 criteria underwent clinical assessments and blood collection to test parasite-specific IgG/IgM serum levels. Twenty-eight patients (27.7%) had IgG anti–T. gondii, and none had IgM antibodies. We found higher prevalence rate in patients aged 40 years or older, as compared with younger. No significant association was detected between T. gondii and a specific diagnostic category; however, bipolar disorder (BD)-II showed the highest positivity rate (40.9%). The seropositive status was significantly associated with a lower presence of psychotic symptoms, higher number of total episodes of predominant excitatory polarity, longer illness duration, and lower severity of current episode, particularly anxiety, depressive, and withdrawal/retardation symptoms. These preliminary results seem to point out an association between chronic toxoplasmosis and a specific subtype of BD. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.