Original ArticlesPreventing Postpartum Depression With Mindful Self-Compassion Intervention A Randomized Control StudyGuo, Lu MD; Zhang, Jing MD; Mu, Liping MD; Ye, Zhao MDAuthor Information Department of Obstetrics and Gynecology, Tianjin First Center Hospital, Tianjin, China. Send reprint requests to Zhao Ye, MD, Department of Obstetrics and Gynecology, Tianjin First Center Hospital, Kangfu Road #24, Nankai District, Tianjin 300192, China. E-mail: email@example.com. Online date: December 24, 2019 The Journal of Nervous and Mental Disease: February 2020 - Volume 208 - Issue 2 - p 101-107 doi: 10.1097/NMD.0000000000001096 Buy Metrics Abstract Mindfulness and self-compassion are reported to have a preventive effects on depression and anxiety disorders. In the present study, we aimed to assess the effect of mindful self-compassion intervention on preventing postpartum depression in a group of symptomatic pregnant women. Participants were screened and assigned to the intervention and control groups randomly. A 6-week Internet-based Mindful Self-Compassion Program was used to train the participants. Multiple scales were used to assess depressive and anxiety symptoms, mindfulness, self-compassion, and mother and infant well-being. All assessments were performed at three time points: baseline, 3 months, and 1 year postpartum. Compared with the control group, the intervention group showed significant improvement in depressive and anxiety behaviors. In addition, the intervention group became more mindful and self-compassionate at 3 months and 1 year postpartum. More importantly, both mothers and infants experienced substantial improvement in well-being. Our findings indicate that mindful self-compassion intervention is effective in preventing postpartum depression and promoting mother and infant well-being. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.