Insomnia is a state defined as trouble with sleep; it is a chronically disabling condition and is now significantly prevalent, imposing enormous health and economic burdens both on individuals and on society. This state includes trouble in falling asleep, problems staying asleep, fragmented sleep (repeatedly awakening at night), and/or awakening before time in the morning. This difficulty in sleeping causes feeling exhausted during the day and trouble with daytime activities including driving, family responsibilities, and completion of valued daily routines. Different types of synthetic sedative drugs are used to handle nervous system changes, but repeated use of sedatives caused tolerance in the human body. After a while, people had to take a heavy dose of sedative to make them feel sleepy, which imposes extra toxic effects on vital organs of the body. Medicinal plants are gaining more and more attention as sedative agents because herbs contained different types of natural bioactive metabolites with not well reported side effects. In addition, medicinal plants have economic, high efficacy and are easy available. So in current review plants possessing sedative activities have been compiled with their constituents responsible to manage insomnia. Review of the literature indicated that medicinal plants from various systems of medicine have been reported to possess sedative activity. This review suggests that medicinal plants are efficacious for insomnia; further laboratory and clinical studies are required.
*Department of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan
†TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative MateriaMedica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China
‡Department of Biochemistry, College of Allied Health Professional, Government College University Faisalabad, Faisalabad
§Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
Send reprint requests to Muhammad Akram, PhD, Department of Eastern Medicine, Government College University Faisalabad, Allama Iqbal Road, 38000, Faisalabad, Pakistan. E-mail: email@example.com.
Authors' Contributions: Dr. Muhammad Akram wrote the initial draft. Dr. Sabira Sultana and Dr. Ejaz Mohiuddin proof read and finalized the article. Dr. Muhammad Daniyal and Naveed Munir revised and critically reviewed the article.