Original ArticlesParanoid Ideation Without Psychosis Is Associated With Depression, Anxiety, and Suicide Attempts in General PopulationNa, Eun Jin MD∗; Choi, Kwan Woo MD†; Hong, Jin Pyo MD, PhD∗; Cho, Maeng Je MD, PhD‡; Fava, Maurizio MD§; Mischoulon, David MD, PhD§; Jeon, Hong Jin MD, PhD∗,∥Author Information ∗Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine †Department of Psychiatry, Anam Hospital, Korea University College of Medicine ‡Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea §Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts ∥Departments of Health Sciences and Technology, Medical Device Management and Research, and Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, South Korea. Send reprint requests to Hong Jin Jeon, MD, PhD, Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul 06351, South Korea. E-mail: [email protected]. The Journal of Nervous and Mental Disease: October 2019 - Volume 207 - Issue 10 - p 826-831 doi: 10.1097/NMD.0000000000001050 Buy Metrics Abstract This study aimed to characterize the association between paranoid ideation without psychosis (PIP) and suicide attempts in a general population. A total of 12,532 adults were randomly selected as the study sample through one-person-per-household method. Subjects completed a face-to-face interview. Among 12,532 subjects, 471 (3.76%) met criteria for the PIP group. The PIP group was younger with more divorced/widowed/separated and lower income than the non-PIP group. The PIP group showed more than fivefold higher lifetime suicide attempt (LSA) rates and ninefold multiple attempt rates than the non-PIP group. Among PIP symptoms, “spouse was being unfaithful” showed the strongest association with LSA (adjusted odds ratio [AOR], 4.49; 95% confidence interval, 2.95–6.85). Major depressive disorder (MDD) in combination with PIP was associated with a higher risk of LSA (AOR, 15.39; 95% confidence interval, 9.63–24.59) compared with subjects without MDD or PIP. In conclusion, PIP, especially “doubting spouse,” was significantly associated with LSA. PIP in combination with comorbid MDD showed higher risk of LSA than subjects without PIP or MDD. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.