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Effect of Cognitive Behavioral Therapy on Improving the Cognitive Function in Major and Minor Depression

He, Hui-Li, PhD*; Zhang, Ming, MD; Gu, Chuan-Zheng, MD*; Xue, Ran-Ran, MD*; Liu, Hong-Xia, MD; Gao, Cai-Feng, MD; Duan, Hui-Feng, MD, PhD§

The Journal of Nervous and Mental Disease: April 2019 - Volume 207 - Issue 4 - p 232–238
doi: 10.1097/NMD.0000000000000954
Original Articles
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The aim of this study was to investigate the effectiveness of cognitive behavioral therapy (CBT) on improving the cognitive function in minor depression (MiD) and major depression (MaD). The study will constitute a placebo-controlled single-blind parallel-group randomized controlled trial. The selected participants will be randomly allocated into one of two parallel groups with a 1:1 ratio: the CBT-based group and the general health education group. CBT significantly alleviated depressive symptoms of MiD and MaD at 12 weeks (p < 0.001), and the treatment effect was maintained for at least 12 months (p < 0.001). Interestingly, CBT significantly promotes more cognitive function of MiD and partial cognitive function of MaD at 12 weeks in the intervention group than in the control group (p < 0.01). CBT can alleviate depressive symptoms of both minor and MaDs. The effectiveness of CBT is different on improving the cognitive function in MiD and MaD.

*The Third Psychiatric Department,

The Fifth Psychiatric Department, and

Department of Psychiatry Rehabilitation, Jining Psychiatric Hospital, Jining, Shandong Province; and

§Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of Chinese PLA, PLA 91st Central Hospital, Jiaozuo, Henan Province, People's Republic of China.

Send reprint requests to Hui-Li He, PhD, and Chuan-Zheng Gu, MD, The Third Psychiatric Department, Jining Psychiatric Hospital, Jining, Shandong Province, 272051, People's Republic of China. E-mail: gcz666@126.com; guchuanzheng120@163.com; and Hui-Feng Duan, MD, PhD, Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of Chinese PLA, PLA 91st Central Hospital, Jiaozuo 454000, Henan Province, People's Republic of China. E-mail: lixiang1110@163.com.

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