Brief ReportSexual Identity Disorder and Psychosis in Klinefelter Syndrome A Synthesis of Literature and a Case ReportMaillefer, Aude MD*; Sabe, Michel MD*; Coste, Christophe MD*; Bartolomei, Javier MD*; Jaafar, Jaafar MD†; Sentissi, Othman MD, PhD*Author Information *Clinique Belle Idée, Department of Mental Health and Psychiatry, and †Endocrinology Unit, Medicine Department, University Hospital of Geneva, Geneva, Switzerland. Send reprint requests to Othman Sentissi, MD, PhD, Department of Mental Health and Psychiatry, University Hospital of Geneva, Cappi Jonction, 35 Rue des Bains, 1205 Geneva, Switzerland. E-mail: [email protected]. The Journal of Nervous and Mental Disease: February 2019 - Volume 207 - Issue 2 - p 121-125 doi: 10.1097/NMD.0000000000000930 Buy Metrics Abstract Klinefelter syndrome (KS) 47, XXY is the most frequent chromosomal abnormality causing hypogonadism in humans. This chromosomal abnormality of number in its classical form called homogeneous (supernumerary X) is generally the result of a meiosis accident. Several studies have suggested that individuals with KS are at greater risk of developing various psychiatric disorders, including depression and schizophrenia. The diagnosis is made based on subnormal testosterone with high pituitary gonadotropins and confirmed by determining the karyotype on a blood simple. We did a literature review using an electronic search in three databases: Pubmed/MEDLINE, Google Scholar, and PsychInfo. We found that since 1989, seven case reports with KS and mental disorders with similar and different characteristics of our case illustration of a patient with KS and psychosis were published. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.