Original ArticlesAssociations of Comorbid Anxiety With Medication Adherence and Psychiatric Symptomatology in a Population of Nonadherent Bipolar Disorder SubjectsAftab, Awais MD*†; Levin, Jennifer PhD*‡; Aebi, Michelle MA*; Bhat, Chetan§; Sajatovic, Martha MD‡∥ Author Information *Department of Psychiatry, Case Western Reserve University School of Medicine; †University Hospitals Cleveland Medical Center; ‡Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center; §Case Western Reserve University School of Medicine; and ∥Neurology and Epidemiology & Biostatistics, Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio. Send reprint requests to Awais Aftab, MD, Department of Psychiatry, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106. E-mail: [email protected]. The Journal of Nervous and Mental Disease: April 2018 - Volume 206 - Issue 4 - p 258-262 doi: 10.1097/NMD.0000000000000788 Buy Metrics Abstract This analysis was conducted on baseline data from 178 nonadherent bipolar disorder subjects in a randomized controlled trial. Medication adherence was measured with Tablets Routine Questionnaire as percentage of days with missed doses. Inclusion criteria required at least 20% nonadherence. Medication adherence, symptomatology, and functioning in individuals with and without a comorbid anxiety disorder were compared. There were 78.9% of subjects who had at least one or more current anxiety disorder, with the most common being posttraumatic stress disorder, panic disorder, and generalized anxiety disorder. The percentage of days with missed doses over the past month was significantly lower in those with anxiety disorders compared with those without (40.1% vs 50.5%, p = 0.03). Those with comorbid anxiety disorders and those with greater number of anxiety disorder diagnoses had significantly worse mean scores on the Montgomery-Åsberg Depression Rating Scale, Brief Psychiatric Rating Scale, Clinical Global Impression–Bipolar Version, and Global Assessment of Functioning. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.