Original ArticlesGeneral Similarities but Consistent Differences Between Early- and Late-Onset Depression Among Korean Adults Aged 40 and OlderPark, Jee Eun MD*; Sohn, Ji Hoon MD, PhD*; Seong, Su Jeong MD†; Suk, Hye Won PhD‡; Cho, Maeng Je MD, PhD*Author Information *Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine and Seoul National University Hospital, Seoul; †Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea; and ‡Department of Psychology, Arizona State University, AZ. Send reprint requests to Maeng Je Cho, MD, PhD, Department of Psychiatry and Behavioral Medicine, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110–744, South Korea. E-mail: [email protected]. The Journal of Nervous and Mental Disease: August 2015 - Volume 203 - Issue 8 - p 617-625 doi: 10.1097/NMD.0000000000000338 Buy Metrics Abstract Differences in clinical characteristics, symptomatology, and psychiatric comorbidity between early-onset depression (EOD) and late-onset depression (LOD) were examined in a nationwide representative sample. The Korean Composite International Diagnostic Interview was used to investigate psychiatric diagnoses and age of onset. A total of 319 subjects aged 40 years and older with a current major depressive disorder (MDD) were included, and both a continuous and a dichotomous (40 years) age-of-onset indicator were used in the analyses. Despite general similarities between groups, EOD was related to chronic (recurrent and longer episode) and severe (higher lifetime suicidality) clinical features. Hypersomnia and suicidal plans/attempts were associated with EOD, whereas anhedonia was related to LOD. Lifetime generalized anxiety disorder was associated with EOD, whereas dysthymic disorder was related with higher age of MDD onset. This study provides additional evidence of consistent differences between EOD and LOD among middle-aged and older Asians. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.