Original ArticlesEye Movement Desensitization and Reprocessing Versus Cognitive-Behavioral Therapy for Adult Posttraumatic Stress Disorder Systematic Review and Meta-AnalysisChen, Ling MD*; Zhang, Guiqing PhD†; Hu, Min MD†; Liang, Xia MD†Author Information *School of Medicine and †Departments of Rehabilitation and Psychology, the First Affiliated Hospital of School of Medicine, Shihezi University, Shihezi, China. Send reprint requests to Guiqing Zhang, PhD, Departments of Rehabilitation and Psychology, the First Affiliated Hospital of School of Medicine, Shihezi University, Shihezi 832008, China. E-mail: email@example.com. The work of the paper is supported by the fund of Xinjiang Production and Construction Corp Science-Technology Project (2012BA023). Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.jonmd.com). The Journal of Nervous and Mental Disease: June 2015 - Volume 203 - Issue 6 - p 443-451 doi: 10.1097/NMD.0000000000000306 Buy SDC Metrics AbstractIn Brief Posttraumatic stress disorder (PTSD) is a relatively common mental disorder, with an estimated lifetime prevalence of ∼5.7%. Eye movement desensitization and reprocessing (EMDR) and cognitive-behavioral therapy (CBT) are the most often studied and most effective psychotherapies for PTSD. However, evidence is inadequate to conclude which treatment is superior. Therefore, we conducted a meta-analysis to confirm the effectiveness of EMDR compared to CBT for adult PTSD. We searched Medline, PubMed, Ebsco, Proquest, and Cochrane (1989–2013) to identify relevant randomized control trials comparing EMDR and CBT for PTSD. We included 11 studies (N = 424). Although all the studies had methodological limitations, meta-analyses for total PTSD scores revealed that EMDR was slightly superior to CBT. Cumulative meta-analysis confirmed this and a meta-analysis for subscale scores of PTSD symptoms indicated that EMDR was better for decreased intrusion and arousal severity compared to CBT. Avoidance was not significantly different between groups. EMDR may be more suitable than CBT for PTSD patients with prominent intrusion or arousal symptoms. However, the limited number and poor quality of the original studies included suggest caution when drawing final conclusions. Supplemental digital content is available in the article. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.