Institutional members access full text with Ovid®

Share this article on:

More Medical Comorbidities in Patients With Bipolar Disorder From the United States Than From the Netherlands and Germany

Post, Robert M. MD*; Altshuler, Lori L. MD; Leverich, Gabriele S. MSW*; Frye, Mark A. MD; Suppes, Trish MD, PhD§; McElroy, Susan L. MD∥¶; Keck, Paul E. Jr. MD∥¶; Nolen, Willem A. MD#; Kupka, Ralph W. MD**; Grunze, Heinz MD††; Rowe, Mike PhD*

The Journal of Nervous and Mental Disease: April 2014 - Volume 202 - Issue 4 - p 265–270
doi: 10.1097/NMD.0000000000000116
Original Articles

Medical comorbidities are common in patients with bipolar (BP) disorder but have not been previously examined for differences between United States and Europe. More than 900 outpatients with BP I and BP II disorder (mean age, 41 years) filled out a questionnaire including the occurrence of 30 listed medical conditions. The patients from the United States were from Los Angeles, Dallas, Cincinnati, and Bethesda, whereas those from Europe were from Utrecht, Freiberg, and Munich. Those from the United States had a significantly higher incidence of obesity and nine other medical comorbidities than those from Europe, who had only more cases of hyperthyroidism. The burden of medical comorbidities in patients with BP disorder from the United States seems higher than in patients from Europe. Given the adversities, morbidity, and early mortality associated with these conditions and their interaction with the morbidity and lethality of BP disorder itself, greater efforts at treatment and prevention of these medical comorbidities would seem indicated.

*Bipolar Collaborative Network, Bethesda, MD; †UCLA Mood Disorders Research Program and VA Medical Center, Los Angeles, CA; ‡Mayo Clinic Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Rochester, MI; §Department of Psychiatry, SW Medical Center, University of Texas, Dallas, TX; ∥Linder Center of Hope, Mason, OH; ¶Biological Psychiatry Program, University of Cincinnati Medical College, Cincinnati, OH; #University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands; **Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands; and ††Newcastle University, Institute of Neuroscience, Newcastle upon Tyne, UK.

Send reprint requests to Robert M. Post, MD, Bipolar Collaborative Network, 5415 West Cedar Lane Suite 201B, Bethesda, MD 20814. E-mail:

© 2014 by Lippincott Williams & Wilkins