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Selective Aggregation of Self-Disorders in First-Treatment DSM-IV Schizophrenia Spectrum Disorders

Haug, Elisabeth MD*; Lien, Lars MD, PhD*†; Raballo, Andrea MD, PhD‡§∥; Bratlien, Unni MD*; Øie, Merete PhD*; Andreassen, Ole A. MD, PhD†¶; Melle, Ingrid MD, PhD†¶; Møller, Paul MD, PhD#

The Journal of Nervous and Mental Disease: July 2012 - Volume 200 - Issue 7 - p 632–636
doi: 10.1097/NMD.0b013e31825bfd6f
Original Articles

Converging evidence indicates that self-disorders (SDs) selectively aggregate in schizophrenia spectrum conditions. The aim of this study was to test the discriminatory power of SDs with respect to schizophrenia and nonschizophrenia spectrum psychosis at first treatment contact. SDs were assessed in 91 patients referred for first treatment through the Examination of Anomalous Self-experience (EASE) instrument. Diagnoses, symptoms severity, and function were assessed using the Structural Clinical Interview for the DSM-IV, Structured Clinical Interview for the Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia, Young Mania Rating Scale, and Global Assessment of Functioning–Split Version. Most patients found it highly relevant to talk about SDs. EASE total score critically discriminated between schizophrenia, bipolar psychosis, and other psychoses. The EASE total score was the only clinical measure that showed a significant and robust association with the diagnosis of schizophrenia. Systematic exploration of anomalous self-experiences could improve differential diagnosis in first-treatment patients.

*Division of Mental Health, Innlandet Hospital Trust, Ottestad, Norway; †Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; ‡Department of Psychiatry, Psychiatric Center Hvidovre, University of Copenhagen, Copenhagen, Denmark; §Psychiatric Intensive Care Unit, Department of Mental Health, AUSL di Reggio Emilia, Reggio Emilia, Italy; ∥Danish National Research Foundation: Center for Subjectivity Research, University of Copenhagen, Copenhagen, Denmark; ¶Institute of Clinical Medicine, University of Oslo, Oslo, Norway; and #Unit of Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Drammen, Norway.

Send reprint requests to Elisabeth Haug MD, Division of Mental Health, Innlandet Hospital Trust, 2312 Ottestad, Norway. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.