Original ArticlesThe Effects of Neuroticism, Extraversion, and Positive and Negative Life Events on a One-Year Course of Depressive Symptoms in Euthymic Previously Depressed Patients Versus Healthy ControlsSpinhoven, Philip PhD*†; Elzinga, Bernet PhD*; Roelofs, Karin PhD*; Hovens, Jacqueline G.F.M. MD†; van Oppen, Patricia PhD‡; Zitman, Frans G. PhD†; Penninx, Brenda W.J.H. PhD†‡§Author Information *Institute of Psychology, Leiden University, Leiden; †Department of Psychiatry, Leiden University Medical Center, Leiden; ‡Department of Psychiatry/EMGO Institute, VU University Medical Center, Amsterdam; and §Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands. The infrastructure for the Netherlands Study of Depression and Anxiety (www.nesda.nl) is funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (Zon-Mw, grant number 10-000-1002) and is supported by the following participating universities and mental health care organizations: VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for Quality of Healthcare (IQ Healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos). The authors have no conflicts of interest to declare. Send reprint requests to Philip Spinhoven, PhD, Leiden University, Institute of Psychology, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands. E-mail: [email protected]. The Journal of Nervous and Mental Disease: September 2011 - Volume 199 - Issue 9 - p 684-689 doi: 10.1097/NMD.0b013e318229d21f Buy Metrics Abstract We investigated a) the concurrent impact of positive and negative life events on the course of depressive symptoms in persons remitted from depression and healthy controls, b) whether the impact of life events on symptom course is moderated by the history of depression and the personality traits of neuroticism and extraversion, and c) whether life events mediate possible relationships of history of depression and personality traits with symptom course. Using data from the Netherlands Study of Depression and Anxiety, we examined 239 euthymic participants with a previous depressive disorder based on DSM-IV and 450 healthy controls who completed a) baseline assessments of personality dimensions (NEO Five-Factor Inventory) and depression severity (Inventory of Depressive Symptoms [IDS]) and b) 1-year follow-up assessments of depression severity and the occurrence of positive and negative life events during the follow-up period (List of Threatening Events Questionnaire). Remitted persons reported higher IDS scores at 1-year follow-up than did the controls. Extraversion and positive and negative life events independently predicted the course of depressive symptoms. The impact of life events on symptom course was not moderated by history of depression or personality traits. The effect of extraversion on symptom course was partly caused by differential engagement in positive life events. © 2011 Lippincott Williams & Wilkins, Inc.