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Associations of Anhedonia and Cognition in Persons With Schizophrenia Spectrum Disorders, Their Siblings, and Controls

Kuha, Annamaria Lic Psych*†; Suvisaari, Jaana MD, PhD*‡; Perälä, Jonna MD*; Eerola, Mervi PhD; Saarni, Suoma S. MD, PhD*; Partonen, Timo MD, PhD; Lönnqvist, Jouko MD, PhD; Tuulio-Henriksson, Annamari PhD*†

The Journal of Nervous and Mental Disease: January 2011 - Volume 199 - Issue 1 - p 30-37
doi: 10.1097/NMD.0b013e3182043a6d
Original Articles
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The aim of the current study was to investigate the levels of social and physical anhedonia, as measured with the Chapman Scales for social and physical anhedonia in groups of patients with schizophrenia spectrum psychosis (n = 91), their unaffected siblings (n = 105), and control subjects drawn from a general population (n = 67). The second aim was to explore the effect of physical and social anhedonia on neuropsychological variables. Subjects with schizophrenia spectrum disorder had significantly more anhedonia than population controls, but the unaffected siblings did not differ from controls. Subjects with schizophrenia spectrum disorders had generalized cognitive deficits. Unaffected sibling status predicted impairments in executive and performance speed measures. Elevated physical anhedonia associated with deficits in verbal functions, but this was not related to genetic liability to schizophrenia. In conclusion, social and physical anhedonia did not seem to mediate neuropsychological deficits of schizophrenia family members.

*Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland; †Department of Psychology, University of Helsinki, Helsinki, Finland; ‡Department of Social Psychiatry, Tampere School of Public Health, Tampere, Finland; §Methodology Centre for Human Sciences, University of Jyväskylä, Jyväskylä, Finland; and ¶Department of Psychiatry, University of Helsinki, Helsinki, Finland.

Supported by grants from the Finnish Cultural Foundation (to A.K.), and the Academy of Finland (grants 116984 [to J.L.], 129434 [to J.S.], and grants 117159 and 131332 [to A.T.-H.]).

Send reprint requests to Annamaria Kuha, Lic Psych, Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, PL 30, 00271 Helsinki, Finland. E-mail: annamaria.kuha@thl.fi.

© 2011 Lippincott Williams & Wilkins, Inc.