Original ArticlesAdvanced Paternal Age, Mortality, and Suicide in the General PopulationMiller, Brian MD, MPH*†; Alaräisänen, Antti MD†; Miettunen, Jouko PhD†; Järvelin, Marjo-Riitta MD, PhD‡§; Koponen, Hannu MD, PhD†¶; Räsänen, Pirkko MD, PhD†; Isohanni, Matti MD, PhD†; Kirkpatrick, Brian MD, MSPH*Author Information *Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia; †Department of Psychiatry, University of Oulu, Oulu, Finland; ‡Division of Epidemiology, Public Health, and Primary Care, Imperial College, London, United Kingdom; §Department of Public Health and General Practice, University of Oulu, Oulu, Finland; and ¶Department of Psychiatry, University of Kuopio, Kuopio, Finland. Supported by the grants from the Academy of Finland (110,143 and 212,848, to M.I.; 125,853, to J.M.), Sigrid Juselius Foundation (to M.I. and A.A.), the University of Oulu (to B.J.M.), Oy H Lundbeck Ab (to B.J.M.), the Duodecim Association (to A.A.), Jalmari and Rauha Ahokas Foundation (to A.A.), Finnish Cultural Foundation (to A.A.), and Orion Research Foundation (to A.A.), The Academy of Finland, Sigrid Juselius Foundation, University of Oulu, the Duodecim Association, Jalmari and Rauha Ahokas Foundation, Finnish Cultural Foundation, Orion Research Foundation and Oy H. Lundbeck Ab had no further role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. Send reprint requests to Brian Miller, MD, MPH, Department of Psychiatry and Health Behavior, Medical College of Georgia, 997 Saint Sebastian Way, Augusta, Georgia 30912. E-mail: firstname.lastname@example.org. The Journal of Nervous and Mental Disease: June 2010 - Volume 198 - Issue 6 - p 404-411 doi: 10.1097/NMD.0b013e3181e07d79 Buy Metrics Abstract Advanced paternal age is a risk factor for adverse health outcomes in the offspring. In a population-based birth cohort from Finland, 10,965 singleton offspring born in 1966 and alive at age 1 were followed to age 39. Hazard ratios were calculated, adjusting for maternal age, gender, paternal social class, and maternal parity. In females but not in males, increasing paternal age was associated with a linear increased risk of suicide (hazard ratio [HR] = 1.13, 95% confidence interval [CI] = 1.04–1.24, p < 0.01) and all-causes mortality (HR = 1.06, 95% CI = 1.01–1.10, p = 0.02). Increasing maternal age was associated with a significantly decreased risk of suicide (HR = 0.93, 95% CI = 0.86–1.00, p = 0.04) and all-causes mortality (HR = 0.96, 95% CI = 0.93–1, p = 0.02) in the entire cohort. For paternal age ≥30, the population attributable risk percentage was 13.7% for all deaths and 7.5% for suicides. Parental age at birth may affect suicide and all-causes mortality risk in the offspring in the general population. The causal pathways and specific disorders associated with this increased mortality are largely unknown. © 2010 Lippincott Williams & Wilkins, Inc.